HBE1 and Hepatic fibrosis: At the time of enrolment, 7/14 HBV mono-infected were HBV e antigen (HBeAg) positive (+) / anti-HBe-negative (-) with a median plasma HBV DNA of 5.4 X 105 IU mL-1 (<20–3.6 x 107 IU mL-1 or ∼100–1.8 x 106 virus copies mL-1), median alanine aminotransferase of 47.5 IU L-1 (range 23–236 IU L-1), and 3/14 had moderate to severe liver fibrosis by transient elastography or liver stiffness measurement.