MMP14 and cancer: MMP14 has been implicated in cancer cell invasion (Hotary et al., 2003) and embryonic development (Holmbeck et al., 1999; Zhou et al., 2000) because of its ability to degrade extracellular matrix (ECM) macromolecules especially type I collagen (Overall, 2001; Tam et al., 2002; Lee et al., 2006; Kessenbrock et al., 2010; Gialeli et al., 2011).