The expression of Ccl8, known to attract actors of allergy and inflammation, was elevated in both Spink5-/- and Spink5-/-Klk5-/- skin (S5C Fig), whereas Ccl20, a chemoattractant for CCR6+ cells including dendritic cells and Th17 cells, showed a significant increase only in Spink5-/- skin (Fig 6D). This evidence concerns the gene CCR6 and allergic disease.