Several serum biomarkers-YKL40, MMP9, B-chain of α2-Heremans-Schmid glycoprotein (AHSG), Haptaglobin α2, Osteopontin and IGFBP2 have been reported to identify glioma [19,20,37,38,39,40]. This evidence concerns the gene IGFBP2 and glioma.