Furthermore, another recent study reported that inhibition of NFκB significantly reduced Gli-1 expression and protein levels in breast cancer cell lines BT549, HS578T, MDA-MB-231, MDA-MB-157, MDA-MB-436, as well as MCF10A [61], and suggested that Gli-1 functions in the maintenance and regulation of cancer stem cells. The gene discussed is GLI1; the disease is breast cancer.