Table 1 shows a summary of the published reports investigating Hh pathway mutations in breast cancer, with rare somatic mutations of Gli-3 also published [15]. It should be emphasized here that even though Hh pathway mutations are rare in breast cancer, similar to many of the other common human malignancies, it has been demonstrated that this pathway is important the pathogenesis of many human cancers including colon cancer [19]. The gene discussed is GLI3; the disease is cancer.