From early time points post-infection, ASFV also promotes the heterochromatinization of the host nucleus by inducing hypermethylation of specific lysine residues of histone H3 (H3K9me3 and H3K27me3), foci formation of the HP1β isoform and redistribution of activated DDR factors (p-p53 and pATR). This evidence concerns the gene TP53 and infection.