EGFR and non-small cell lung carcinoma: Similarly, a whole cell-SELEX experiment on human non-small-cell lung cancer cells (NSCLC) with 2′-fluoropyrimidine-modified NTPs allowed Esposito et al. to isolate a rather short (39 nucleotides) aptamer that could inhibit the epidermal growth factor receptor (EGFR) through tightly binding to the lung cancer cell line A549 (Kd = 38 nM) and could discriminate these targets from H460 cells [61].