APOA1 and brain disorder: Other peroxidases play major roles in cardiovascular, lung and brain diseases (Al Ghouleh et al., 2011; Shao, 2012; Rodríguez-Rodríguez et al., 2014) such as myeloperoxidase, a heme enzyme secreted by human artery wall macrophages which oxidizes apolipoprotein A-I (apoA-I), the major HDL protein, diminishing apoA-I ability to promote cellular cholesterol efflux.