YAP1 is elevated in human tumors and correlates with increased proliferation and clinical outcomesCopy number gains of the YAP1 locus are reportedYAP suppression results in decreased proliferation and increased differentiationMyf5- or Myod1-hYap1 S127A mice generate ERMS tumors within 4–8 weeks after Yap1 S127A expression100% of Pax7-hYap1 S127A mice generate ERMS-like tumors within 10–11 weeks after injury. This evidence concerns the gene MYOD1 and embryonal rhabdomyosarcoma.