TBX5 and cancer: Rosenbluh et al. performed genome-scale loss-of-functions screens on 85 cancer cell lines (including osteosarcoma) and determined that WNT-active cancers are dependent upon β-catenin forming a complex with YAP and the transcription factor TBX5 to promote transcription of anti-apoptotic genes that are essential for cancer cell transformation and survival (58).