Nephrolithiasis, however, was significantly (p = 0.011) more frequent in adults (12/28) than in children (3/30), but the median age of adult patients with nephrolithiasis was significantly lower in CLCN5+ than in CLCN5− group (23 vs. 42 p = 0.012). Here, CLCN5 is linked to nephrolithiasis.