Using IPA analysis, to identify upstream regulators for the differentially expressed genes in stage II CRC samples used in this study, we observed a strong enrichment for tumor suppressor TP53 family members and oncogenic TFs (i.e.NFKB, AP1 and MYC) that either individually or combined regulate gene expression through shared or unique target genes (Fig. 2; Additional file 1: Table S1). The gene discussed is MYC; the disease is colorectal carcinoma.