HMGB1 and neoplasm: Finally, we selected 8 out of the above 10 genes from above list (RPN2, HMGB1, AARS, IGFBP3, STAT1, HYOU1, NQO1 and PEA15), based on the following criteria: (1) previously identified by CRC tumor microarray experiments; (2) previously published as a prognosis markers and (3) identified candidate within the transcriptional regulation network presented in Fig. 2.