In The Cancer Genome Atlas (TCGA) database [46], NFE2L2 (Nrf2) levels also varied markedly in normal colon and in colon tumors and were inversely correlated with Cdkn2a/p16 (Fig. 9), in accordance with data from cell-based, preclinical, and translational studies reported here. The gene discussed is NFE2L2; the disease is colonic neoplasm.