Based on prior reports linking Cdkn2a and HDAC3 [23–25], we performed chromatin immunoprecipitation (ChIP) assays in vivo and observed HDAC3 interactions on the p16 proximal promoter region to be lower in colon tumors of Nrf2−/+ mice compared with WT (Fig. 6f, black vs. grey bars), especially after SFN treatment (green bars). This evidence concerns the gene CDKN2A and colonic neoplasm.