CD19 and lymphoma: In the preclinical setting, first generation CAR-T cells against CD19 or CD20 (CD19-/CD20-ζ) showed adequate engraftment and anti-lymphoma activity in either mice xenografted with patients’ tumors and autologous CAR-T cells or in syngeneic murine models following lymphodepletion with cyclophosphamide or radiation (90–93).