BCR and B-cell non-Hodgkin lymphoma: Mutations in pro-apoptotic genes (CD95), tumor-suppressor genes (TP53, PTEN), BCR downstream signaling pathways (CD79B/A, IκBα, CARD11, API2–MALT1 translocation) and other oncogenes (EZH2, Jak2, genomic amplifications REL) are associated to specific subtypes of B-cell lymphomas, indicating a role of these events in their pathogenesis (Table 1).