I. Antigen presentation to CD4+ T cellsDC (27)II. Accumulation of Th17 cells DC (28)III. TNFa, TGFb production DC (28, 68) Macrophages (68)IV. Tubular apoptosis DC (68) Macrophages (68)V. Renal fibrosis DC (68, 69) Macrophages (68, 69). This evidence concerns the gene TGFB1 and renal fibrosis.