ISG15 and infection: Additionally, as shown in Figures 7I–K, both infections significantly increased the transcription of IFITM1, ISG15 and Viperin, and a 50 μM LY294002 treatment (Figure 7I) or knockdown of Akt (Figure 7J) or knockdown of EMSY (Figure 7K) reduced the mRNA levels of IFITM1, ISG15, and Viperin.