CTSB and subarachnoid hemorrhage: Treating subarachnoid hemorrhage models with iron chelators deferoxamine or α-lipoic acid protected lysosomal membranes and prevented cathepsin B leakage, which correlated with improved outcomes, such as reductions in brain edema, blood–brain-barrier impairment, and neuronal cell death, and also improved behavioral deficits (102, 103).