MAPT and Atrophy: Bilateral anterior striatal atrophy is particularly prominent in the head of the caudate nucleus, which appears to be significantly greater in FTLD-FUS compared with FTLD-TDP and FTLD-tau, suggesting that severe caudate atrophy may be a useful clinical feature to predict FTLD-FUS pathology (Josephs et al., 2010; Lee et al., 2012).