TARDBP and amyotrophic lateral sclerosis: So far, mutations in the TARDBP gene account for 2–3% of ALS patients (Gitcho et al., 2008; Kabashi et al., 2008; Kühnlein et al., 2008; Rutherford et al., 2008; Sreedharan et al., 2008; Van Deerlin et al., 2008; Yokoseki et al., 2008; Daoud et al., 2009).