TREM2 and frontotemporal dementia: Recently, Borroni and colleagues evaluated the frequency of heterozygous TREM2 mutations as risk factor in FTD patients, confirming that the Q33X, R47H, and T66M mutations were significantly associated with the disease and absent in healthy subjects (Borroni et al., 2013), in line with further reports (Cuyvers et al., 2013).