GRN and Atrophy: Neuroimaging studies have highlighted that patients carrying a GRN mutation are more likely to show a pronounced asymmetrical atrophy (Huey et al., 2006; Bronner et al., 2007; Beck et al., 2008; Pickering-Brown et al., 2008) affecting either the left or right hemispheres, involving primarily the inferior frontal (Bronner et al., 2007; Beck et al., 2008; Ghetti et al., 2008), temporal and inferior parietal lobes (Mesulam et al., 2007; Pickering-Brown et al., 2008), as well as long intrahemispheric association white matter (WM) tracts (Borroni et al., 2008; Rohrer and Warren, 2011).