In some cases, episodic memory impairment has been observed in patients with MAPT mutations, in particular in the R406W mutation, mimicking Alzheimer’s disease (AD) (Tolboom et al., 2010), or in the recently described duplication of the MAPT gene, where the predominant memory impairment was preceded by clinical symptoms characteristic of bvFTD (Rovelet-Lecrux et al., 2010). Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.