MAPT and supranuclear palsy, progressive, 1: At first, neuronal and glial inclusions of hyperphosphorylated tau protein were identified in FTLD-tau, which represent nearly 30–40% of FTLD cases, and are found in patients carrying MAPT gene mutations, as well as in Pick’s disease, PSP, and corticobasal degeneration (CBD) (Josephs et al., 2006).