Furthermore, the inclusions positive for FUS were found to also stain for other members of the FET family of DNA/RNA-binding proteins, comprising the TATA-binding protein-associated factor 15 (TAF-15) and Ewing sarcoma protein (EWS), distinguishing FTLD with FUS pathology from ALS with FUS mutations (Neumann et al., 2011). The gene discussed is EWSR1; the disease is amyotrophic lateral sclerosis.