Different pathogenic mechanisms in ALS-FUS and FTLD-FUS also arise from a recent study in which, in ALS-FUS, no co-accumulation of other FET-proteins into FUS-positive inclusions was found, in remarkable contrast to FTLD-FUS, in which TAF-15 and EWS were found to co-accumulate in FUS-positive cytoplasmic inclusions (Neumann et al., 2011). Here, EWSR1 is linked to amyotrophic lateral sclerosis.