PLAT and intracranial hemorrhage: Several small randomized trials of IV tPA suggested its safety efficacy in AIS (Mori et al., 1992; Haley et al., 1993), but large, randomized trials of another thrombolytic drug, intravenous streptokinase, were stopped early because of unacceptable rates of symptomatic intracranial hemorrhage (sICH; Donnan et al., 1995; Hommel et al., 1995).