These DUBs can be subdivided into five different classes: (1) the UCHs; (2) the ubiquitin specific proteases (USPs); (3) the ovarian tumor proteases (OTUs); (4) the Machado-Joseph Disease protein domain proteases (MJDs); and (5) the JAB1/MPN/Mov34 metalloenzymes (JAMMs; Todi and Paulson, 2011). The gene discussed is COPS5; the disease is neoplasm.