Cadm1 is highly expressed in the dendritic arbor of Purkinje neurons and Cadm1 knockout mice demonstrate reductions in cerebellar size (Fujita et al., 2012) and abnormal social behaviors, abnormal vocalizations, increased anxiety, and abnormal motor coordination (Takayanagi et al., 2010; Fujita et al., 2012). The gene discussed is CADM1; the disease is Anxiety.