Based on bioinformatics analysis, we detected the Cthrc1 mRNA expression and found elevated expression of Cthrc1 was also associated with the occurrence of the differentiation status, TNM stage and lymph node metastases in NSCLC patients, and Pearson correlation analysis indicated that the expression of miR-30b and Cthrc1 mRNA were inversely correlated. The gene discussed is CTHRC1; the disease is non-small cell lung carcinoma.