Western blotting array was used to analyze the expression of invasion-related proteins and the results showed that Cthrc1, MMP-9 and MMP-2 were declined but TIMP-1 was increased following transfection with miR-30b in A549 and Calu-3 cells, which is a hint that miR-30b plays an important role in cell migration and invasion of NSCLC. Here, CTHRC1 is linked to non-small cell lung carcinoma.