To further understand the effect of miR-125b on the metastasis of human NSCLC, we predicted the targets of miR-125b by prediction programs including TargetScan and PicTar, and selected eight possible target including STARD13, ZNF792, SH3TC2, IRF4, FUT4, BAK1, ARID3B, and TP53INP1 for real time PCR analysis. This evidence concerns the gene ARID3B and non-small cell lung carcinoma.