To further understand the effect of miR-125b on the metastasis of human NSCLC, we predicted the targets of miR-125b by prediction programs including TargetScan and PicTar, and selected eight possible target including STARD13, ZNF792, SH3TC2, IRF4, FUT4, BAK1, ARID3B, and TP53INP1 for real time PCR analysis. The gene discussed is BAK1; the disease is non-small cell lung carcinoma.