PRKCG and cancer: Given that PKCγ is a critical regulator of migration in development (Kramer et al., 2002), that it has been linked to metastasis (Yang et al., 2014), and that its overexpression in epithelial cells triggers a malignant phenotype and tumorigenic behavior in vivo (Mazzoni et al., 2003), we speculate that these specificity drifts ReKINect has predicted could provide tumorigenic, invasive, and metastatic capabilities to cancer cells.