Given that protein kinases are one of the protein classes most frequently encoded by cancer genes (Futreal et al., 2004) and mutated in cancer (Figure S1) as well as a major molecular target of therapeutic drugs (Anastassiadis et al., 2011, Davis et al., 2011), it is essential to identify how phosphorylation-based signaling networks drive cancer. The gene discussed is WEE1; the disease is cancer.