Build‐up of AcCoA has been observed in alcoholic fatty liver disease, where acetate produced by mitochondrial aldehyde dehydrogenase 2 from ethanol‐derived acetaldehyde is converted to AcCoA, but its further metabolism via the citric acid cycle is limited due to product inhibition of isocitrate dehydrogenase and α‐ketoglutarate dehydrogenase by NADH produced during acetaldehyde oxidation 43. This evidence concerns the gene IDH3A and alcoholic fatty liver disease.