In addition to decreasing eosinophilia, mice pre-treated with NP-CpG before sensitization and challenge with HDM (Fig. 2A) displayed significantly more CD11c+ MHCII+ DCs in the lungs than untreated mice or mice pre-treated with free CpG (Fig. 3A). The gene discussed is ITGAX; the disease is Increased total eosinophil count.