Although most TNBCs classify as the basal-like subtype, the terms TNBC and basal-like breast cancer are not synonyms; approximately 20% to 30% of clinical TNBCs are not basal-like by microarray analysis, and a not negligible number of basal-like breast cancers express ER/PR or HER2 [12, 20]. Here, ESR1 is linked to breast carcinoma.