APOC3 and coronary artery disorder: There were 3 studies that reported the association between CHD and APOC3 -455 T > C and meta-analysis results indicated that under allele model and dominant gene model -455 T > C SNP had potential to increase the risk of CHD (allele: OR = 0.64, 95 % CI = 0.51 ~ 0.80, P < 0.001, Fig. 3a; dominant: OR = 0.57, 95 % CI = 0.43 ~ 0.75, P < 0.001, Fig. 3b).