EGFR and neoplasm: In patients with advanced or metastatic colorectal treatment with monoclonal antibodies directed against the epidermal growth factor receptor (EGFR), cetuximab and panitumumab are proven to be active after failing fluoropyrimidine, oxaliplatin and irinotecan based regimens, though only in patients with tumours without a mutation in the KRAS [2, 3] or more recently RAS gene [4].