KIAA0586 and polycystic kidney disease: Talpid3 chicken embryos also have polycystic kidneys (Yin et al., 2009), a phenotype that is frequently ascribed to a loss of oriented cell division (Happe et al., 2011; Carroll and Yu, 2012), as well as cell migration defects (Bangs et al., 2011), which may also occur due to loss of cell polarity (Happe et al., 2011; Carroll and Yu, 2012).