The talpid3 chicken is a thoroughly examined animal model with polydactyly, holoprosencephaly, abnormal neural tube patterning, polycystic kidneys, liver fibrosis, short ribs, and endochondral bones with defective ossification (Lewis et al., 1999; Buxton et al., 2004; Davey et al., 2006; Davey et al., 2014). This evidence concerns the gene KIAA0586 and holoprosencephaly.