A few over-expressed genes in cancer are also located in the amplified region of 11q13.3, including MYEOV (myeloma over expressed) [52], ORAOV1 (oral cancer over expressed gene 1) [53], ANO1 in head and neck squamous cell carcinoma [54], and CTTN in breast cancer and squamous cell carcinomas of the head and neck [55,56]. The gene discussed is LTO1; the disease is breast cancer.