BIRC2 and cancer: This resulted in the amplification of several oncogenes, including CCND1, FGF3, FGF4, and FGF19, and the deletion of the tumor suppressor genes CDKN2A and CDKN2B. In addition, the region with focal amplification in 11q22.1 (Q = 1.25 × 10−6, 9/55) contains several cancer-related genes, including YAP1, which has been reported in the liver and colorectal cancers [20–22], as well as BIRC2 and BIRC3, which activate the NF-κB signaling pathway (KEGG pathway database, http://www.genome.jp/kegg/pathway.html).