CACNA1D and psychiatric disorder: In the brain, L-type calcium channels, including CaV1.3, play a role in the pacemaker activity in brain dopaminergic neurons (Guzman et al., 2009, Liu et al., 2014), and CaV1.3 is also involved in synaptic pruning during development (Hirtz et al., 2012), two processes whose disruption might be likely to be implicated in psychiatric disorders (for review, see Striessnig et al., 2014).