CACNB2 and schizophrenia: It is important to note that some identified SNPs are associated with a specific susceptibility to either bipolar disorder or schizophrenia, whereas for two of the genes, CACNA1C and CACNB2, the SNPs were found to confer susceptibility to schizophrenia, bipolar disorder, and also to major depressive disorder (Green et al., 2010, Cross-disorder group of Psychiatric Genomics Consortium, 2013).