A previous study of 127 female RA patients, followed for 6 years, showed that patients with a higher percentage of agalactosyl IgG oligosaccharides G(O) in serum had significantly more erosions and disease activity than patients with lower levels.3 Therefore, we tested the association of glycosylation SNPs with both response to anti-TNF therapy and disease severity in RA patients but found no evidence to support the theory that glycosylation SNPs predict outcome. The gene discussed is TNF; the disease is rheumatoid arthritis.