Our data corroborate recently reported data suggesting upregulation of NLRP3-inflammasome-related gene expression in mononuclear cells (PBMCs) in peripheral blood from patients with active RA [17] and earlier data showing increased NALP3 mRNA levels in the synovium in RA compared with osteoarthritis (OA) [18]. The gene discussed is NLRP3; the disease is rheumatoid arthritis.