Comparing the CXCL10 and CXCL13 levels according to existence of RHS, we found that serum CXCL13 were significantly higher in AOSD patients with RHS (229.6 ± 90.3 pg/mL) than in patients without RHS (151.6 ± 157.6 pg/mL, p = 0.039), but serum CXCL10 did not differ between the two groups. Here, CXCL13 is linked to adult-onset Still disease.