Furthermore, the percentages of apoptosis cells in FANCL depleted cells were markedly higher than those in FANCF depleted cells, when treatment with 10 μg/ml and 20 μg/ml cisplatin (Fig. 7d, P = 0.001 and P < 0.001), indicating that knockdown of FANCF or FANCL by siRNA could synergize the effect of cisplatin on inducing apoptosis of cisplatin-resistant lung cancer cells through suppressing FA/BRCA pathway. The gene discussed is FANCL; the disease is lung cancer.