Ninety percent of FA patients carry mutations in one of the components of the FA core complex, including FANCA (NP_000126.2), FANCB (NP_001018123.1), FANCC (NP_000127.2), FANCE (NP_068741.1), FANCF (NP_073562.1), FANCG (NP_004620.1), FANCL (NP_001108108.1) and FANCM (NP_001295063.1) [21]. The gene discussed is FANCC; the disease is Friedreich ataxia.