Cancer cells expressing CXCR4 metastasize to tissues that highly produce SDF-1 including bone marrow [12]; MM cells express CXCR4 and migrate to the bone marrow niche where interaction with osteoclasts and bone marrow stroma cells enhances MM cell survival and proliferation [4, 9, 10]. This evidence concerns the gene CXCR4 and Miyoshi myopathy.