SLC16A3 and nonpapillary renal cell carcinoma: In clear cell renal cell carcinoma (ccRCC), which is characterized by a glycolytic Warburg phenotype, MCT4 has not only been shown to be a metabolic target to reverse the Warburg effect [7], as shown by Gerlinger et al in a genome-wide siRNA screening study in RCC cell lines, but is also proposed to be a prognostic marker for patient outcome.