BCL9 and ductal breast carcinoma in situ: As shown in Fig. 5c, BCL9 KD DCIS.COM and SUM225 MIND lesions showed a significant reduction in the maximum distance of invasion (DCIS.COM = 78.0 ± 22.3 μm in KD compared to 302.7 ± 12.4 μm in control and for SUM225 = 75.5 ± 18.9 μm in KD compared to 338.3 ± 18.8 μm in control; p <0.05) and in the number of invasive lesions per field compared to the control (DCIS.COM = 1.4 ± 0.5 in KD compared to 4.3 ± 0.9 in control and for SUM225 = 3.0 ± 3.0 invasive lesions in KD compared to 11.7 ± 1.2 invasive lesions in control; p <0.05).