Indication for bridging therapy was a mechanical heart valve in 18 (14 aortic, two mitral, two both), biological heart valve in two, atrial fibrillation (AF) in three (CHADS2 score 5/6 and/or persistent AF), previous pulmonary embolism in six, hypercoagulopathy in three (one patient with Factor-V-Leiden and recurrent DVT and PE in combination with AF, one patient with hyperhomocysteinemia and protein C deficiency with previous DVT and one patient with hyperhomocysteinemia with recurrent DVT despite OAC), and an in-stent coronary stenosis in one patient. This evidence concerns the gene F5 and protein c deficiency.