To validate the possible role of Sur8 in the metastasis of human melanoma and to confirm our in vitro findings showing an association between Sur8 and activation of Akt, ERKs, and Rac, we utilized a tissue microarray (TMA; ME2082b; US Biomax) consisting of human metastatic melanoma (n = 64) and normal skin tissue (n = 15) specimens. This evidence concerns the gene SHOC2 and melanoma.