We quantified results of the immunohistochemistry (IHC) stainings using HistoQuest software (TissueGnostics, Vienna, Austria) and observed that Sur8, p-Akt, p-ERK, and GTP-Rac were highly expressed in the identical human metastatic melanoma tissues compared with normal skin tissues (Figure 7A–7E). This evidence concerns the gene AKT1 and metastatic melanoma.