Gupta et al. initially indicated that HOTAIR expression was up-expressed in breast cancer tissues, as well as be related to breast cancer progression [4]; and further studies showed that HOTAIR could induce genome-wide retargeting of Polycomb repressive complex 2 (PRC2), contributing to altered H3 lysine 27 methylation [4, 9]. Here, HOTAIR is linked to breast carcinoma.