ARID1A and cancer: Conversely, loss of ARID1A was associated with an increased risk of death due to cancer in three studies [16, 17, 27] compared to presence of ARID1A (138/303 = 45.5% vs. 25/130 = 19.2%; RR = 1.55, 95%CI: 1.19–2.00, p = 0.001, I2 = 31%) as shown in Table 1 and in Supplementary Figure 4.