Treatment with rIFN-αA/D resulted in significantly reduced production of IL-4, but not of IFN-γ and IL-17A, on day 14 after infection with C. neoformans (Fig 8), which was consistent with our hypothesis raised by the current data with IFNAR1KO mice suggesting that type I IFNs may have detrimental effects on the early host defense to this infection by suppressing the Th1 and Th2 immune response. The gene discussed is IFNG; the disease is infection.