Type II interferon designated as IFN-γ, which is secreted from Th1 cells, and some innate lymphocytes such as natural killer (NK) cells, NKT cells, and γδT cells [13–17], strongly induces classically activated macrophages (M1) to kill C. neoformans via a nitric oxide (NO)-dependent mechanism [10, 18, 19] and promotes the containment of this fungal pathogen within granulomatous tissues [12], leading to improvement of the infection. The gene discussed is IFNG; the disease is infection.