The etiology of hypertension among these patients appears to be multifactorial and potentially involves elastin haploinsufficiency, neutrophil cytosolic factor 1 hemizygosity [27], reduced nicotinamide adenosine dinucleotide phosphate-oxidase-mediated oxidative stress [28], an activated RAA system, and renovascular disease. The gene discussed is NCF1; the disease is hypertensive disorder.