APOE and Alzheimer disease: The cognitively normal group in the current study was biased towards patients who showed decline (six patients progressed to MCI and four patients to dementia), and the percentage of APOE ε4 carriership in our cognitively normal group was higher than reported in the previous studies (i.e., 42 % vs. 17–29 %) [27, 43], and higher than in the general population (20–25 %) [38], suggesting a potentially higher prevalence of preclinical AD in this population.