In line with that, studies conducted by Qin et al. and Huerta et al. reported on radiosensitization of esophageal carcinoma cells by the compound LCL161 [43], while the compound JP-1201 was shown to sensitize HT-29 colorectal carcinoma cells in vitro and in a SCID mouse xenograft model in conjunction with enhanced Poly(ADP-ribose) polymerase-1 (PARP-1) cleavage [43]. The gene discussed is PARP1; the disease is carcinoma of esophagus.