However, recent large-scale studies reported that, among patients with T2DM who had experienced acute coronary syndrome recently, the prevalence of major adverse cardiovascular events was not increased or decreased with the DPP-4 inhibitors saxagliptin [12] or alogliptin [13], as compared with placebo despite better control of HbA1c levels with both DPP-4 inhibitors than with placebo. This evidence concerns the gene DPP4 and acute coronary syndrome.