Levels of adiponectin were higher in patients with nephropathy (21.84 ± 8.15 vs 14.88 ± 8.27 mg/ml, p = 0.008), but not regarding the presence of retinopathy; neither TNF- α, nor IL-6 and IL-1β showed differences regarding the presence of microvascular disease. This evidence concerns the gene IL1B and Nephropathy.