The pathophysiologic mechanisms hypothesized to play a role in the development of statin-induced myalgias include competition at the cytochrome P-450 (CYP3A4) enzyme [6], deficiency of mitochondrial enzyme CoQ [7, 10] decreased plasma clearance in older patients [8], and/or vitamin D deficiency [6]. This evidence concerns the gene CYP3A4 and Myalgia.